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Drug and human trafficking is not only a global issue affecting everyone from all corners of the world but also an extensive and prevalent threat to peace and security in Africa. The challenges of drug trafficking has risen above all five regions of the continent where some are experiencing a rapid and disastrous decline. Besides engaging in illegal cultivation, manufacture, distribution and sale of prohibited substance, drug trafficking fosters other forms of crime, such as money laundering, corruption etc. It is also employed to raise income necessary to acquire weapons either by corrupting government officials responsible for the enforcement of law, the military or by misusing funds allocated to conflict resolution. This among others further set hurdles and lengthen the duration of armed conflicts making them more fatal. It is also an ideal source of money for terrorist groups, sustaining crime, criminal acts and deteriorating the rule of law. The continent is not only a major transit route in the international trade of controlled drugs but also major consumer and distributer. Coupled with the youth bulge and growing level of unemployment, this scenario pauses further threats to security in Africa.